Terazosin hydrochloride( Terazocin HCl | Vasocard | Hyprin | A-45975 | A 45975 | A45975 )

Catalog No. M15384 CAS No. 63074-08-8

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Product Name

Terazosin hydrochloride
Note

Research use only, not for human use.
Brief Description

Terazosin is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (BPH).
Description

Terazosin is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (BPH). It also acts to lower blood pressure, so it is a drug of choice for men with hypertension and prostate enlargement. It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.(In Vitro):Terazosin does not discriminate cloned α1-adrenoceptor subtypes transiently expressed in COS cells.(In Vivo):Terazosin can be used to promote stone discharge in treatment of ureteral stones. Terazosin is reportedly safe and effective in treatment of distal ureteral stones, especially stones >5 mm.
In Vitro

Terazosin does not discriminate cloned α1-adrenoceptor subtypes transiently expressed in COS cells.
In Vivo

Terazosin can be used to promote stone discharge in treatment of ureteral stones. Terazosin is reportedly safe and effective in treatment of distal ureteral stones, especially stones >5 mm.
Synonyms

Terazocin HCl | Vasocard | Hyprin | A-45975 | A 45975 | A45975
Pathway

Endocrinology/Hormones
Target

Adrenergic Receptor
Recptor

α-adrenergic receptor
Research Area

Metabolic Disease
Indication

——

CAS Number

63074-08-8
Formula Weight

423.89
Molecular Formula

C19H26ClN5O4
Purity

>98% (HPLC)
Solubility

Water: 50 mM
SMILES

O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4OCCC4.[H]Cl
Chemical Name

Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)-, monohydrochloride

1.Lee E, Lee C. Br J Urol. 1997 Oct;80(4):606-1

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